Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis
نویسندگان
چکیده
منابع مشابه
miR‐373 regulates inflammatory cytokine‐mediated chondrocyte proliferation in osteoarthritis by targeting the P2X7 receptor
Inflammatory cytokines commonly initiate extreme changes in the synovium and cartilage microenvironment of osteoarthritis (OA) patients, which subsequently cause cellular dysfunction, especially in chondrocytes. It has been reported that induction of the purinergic P2X7 receptor (P2X7R) can regulate the expression of a variety of inflammatory factors, including interleukin (IL)-6 and -8, leadin...
متن کاملChondrocyte Apoptosis in the Pathogenesis of Osteoarthritis
Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA), the most common chronic joint disease in the elderly population, is characterized by progressive destruction of articular cartilage, resulting...
متن کاملEndogenous miR-29a regulates HSC function in mammals.
subgroup analyses are hypothesis generating at best. An ongoing randomized controlled trial will hopefully shed further light on the potential benefit of LMWH to prevent recurrent pregnancy loss in thrombophilic women (www. trialregister.nl #NTR 3361). The bottom line is that we need further research to explore whether LMWH can improve live birth rates in women with thrombophilia. However, unti...
متن کاملmiR-181a Modulates Chondrocyte Apoptosis by Targeting Glycerol-3-Phosphate Dehydrogenase 1-Like Protein (GPD1L) in Osteoarthritis
BACKGROUND miR-181a is a small non-coding RNA known to be dysregulated in osteoarthritis (OA), but the role of miR-181a in human OA remains unclear. The aim of this study was to identify its function and molecular target in chondrocytes during OA pathogenesis. MATERIAL AND METHODS The function of miR-181a was assessed by gain-of-function studies in human OA chondrocytes. Potential targets of mi...
متن کاملMiR‐29b‐3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN
This study was aimed to explore the role of miR-29b-3p and PGRN in chondrocyte apoptosis and the initiation and progress of osteoarthritis (OA). Both miR-29b-3p and PGRN were up-regulated in cartilage tissue from patients with OA. Transfection of miR-29b-3p mimic into rat primary chondrocytes and SW1353 chondrosarcoma cells significantly suppressed PGRN expression and release, induced apoptosis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BioMed Research International
سال: 2019
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2019/1434538